Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.52 |
| ▸ | CLK1 | P49759 | 5/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.52 |
| ▸ | CLK2 | P49760 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725579 | 0.89 | DYRK1A (0.65) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL3723906 | 0.86 | PTGS2 (0.51) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL3724659 | 0.82 | DYRK1A (0.51) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL3720901 | 0.78 | HPGD (0.47) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL3723229 | 0.76 | ADORA1 (0.48) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL3721197 | 0.76 | ADORA1 (0.51) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL3722007 | 0.74 | CLK4 (0.71) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL3721028 | 0.73 | ADORA1 (0.48) | MEN1KMT2AHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL10203365 | 0.72 | LMNA (0.57) | ALDH1A1MAPTTSHRLMNASMN1; SMN2 | |
| SCHEMBL3719658 | 0.72 | DYRK1A (0.49) | CLK4CLK1DYRK1ADYRK1BCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |