Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717907 | 0.86 | CLK4 (0.52) | MAPTDYRK1AALDH1A1CLK1CLK4 | |
| SCHEMBL3725579 | 0.86 | DYRK1A (0.65) | PTGS2MAPTDYRK1AALDH1A1CLK1 | |
| SCHEMBL3724659 | 0.79 | DYRK1A (0.51) | PTGS2MAPTDYRK1ACLK1CLK4 | |
| SCHEMBL3720901 | 0.78 | HPGD (0.47) | MAPTDYRK1AALDH1A1CLK1CLK4 | |
| SCHEMBL3723229 | 0.76 | ADORA1 (0.48) | DYRK1AALDH1A1CLK1CLK4DYRK1B | |
| SCHEMBL3721197 | 0.75 | ADORA1 (0.51) | MAPTDYRK1ACLK1CLK4DYRK1B | |
| SCHEMBL22100264 | 0.74 | ALDH1A1 (0.61) | PTGS2MAPTDYRK1AALDH1A1LMNA | |
| SCHEMBL14458159 | 0.74 | PTGS2 (0.87) | PTGS2MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3721028 | 0.73 | ADORA1 (0.48) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL17545085 | 0.73 | MAPT (0.49) | PTGS2MAPTALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |