SCHEMBL3727016

SCHEMBL3727016

NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCN(Cc3ccncc3)CC2)n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 3/20 0.53
CASP5 P51878 3/20 0.53
CASP4 P49662 2/20 0.53
TSHR P16473 1/20 0.46
RORC P51449 3/20 0.44
SRPK1 Q96SB4 2/20 0.44
HIF1A Q16665 1/20 0.43
EPAS1 Q99814 1/20 0.43
ACHE P22303 1/20 0.43
PARP1 P09874 1/20 0.43
PARP2 Q9UGN5 1/20 0.43
SLC2A1 P11166 1/20 0.43
PPARG P37231 1/20 0.42
ALDH1A1 P00352 2/20 0.42
RPS6KB1 P23443 1/20 0.42
MAPT P10636 1/20 0.42
PRKCI P41743 1/20 0.41
CHKA P35790 1/20 0.41
KDM4E B2RXH2 2/20 0.40
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3717051 0.89 KDM4E (0.54) CASP1CASP5CASP4TSHRSRPK1
SCHEMBL3717029 0.85 SRPK1 (0.46) CASP1CASP5CASP4SRPK1ALDH1A1
SCHEMBL3797918 0.85 HRH4 (0.44) CASP1CASP5CASP4TSHRALDH1A1
SCHEMBL3721798 0.84 ALDH1A1 (0.45) CASP1CASP5CASP4TSHRACHE
SCHEMBL3720812 0.84 LMNA (0.59) CASP1CASP5CASP4ALDH1A1KDM4E
SCHEMBL3727012 0.83 PARP1 (0.51) CASP1CASP5CASP4TSHRRORC
SCHEMBL3724664 0.82 HRH4 (0.57) ALDH1A1MAPTKDM4E
SCHEMBL3721072 0.82 CYP11B2 (0.46) CASP1CASP5CASP4TSHRALDH1A1
SCHEMBL3717694 0.82 TSHR (0.43) CASP1CASP5CASP4TSHRPARP1
SCHEMBL3724014 0.80 HRH4 (0.43) CASP1CASP5CASP4TSHRSRPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed