Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13124618 | 0.87 | HSD11B1 (0.61) | HSD11B1POLBTDP1HSD17B1CNR2 | |
| SCHEMBL3799204 | 0.83 | HSD11B1 (0.66) | HSD11B1POLBTDP1HSD17B1CNR2 | |
| SCHEMBL3659658 | 0.83 | HSD11B1 (0.36) | HSD11B1PDE4BALDH1A1 | |
| SCHEMBL3799202 | 0.83 | HSD11B1 (0.66) | HSD11B1POLBTDP1HSD17B1CNR2 | |
| SCHEMBL3661604 | 0.80 | ALDH1A1 (0.40) | HSD11B1POLBTDP1PDE4BALDH1A1 | |
| SCHEMBL3794868 | 0.80 | HSD11B1 (0.60) | HSD11B1POLBTDP1CNR2PDE4B | |
| SCHEMBL3796683 | 0.80 | HSD11B1 (0.60) | HSD11B1POLBTDP1CNR2PDE4B | |
| SCHEMBL3794865 | 0.80 | HSD11B1 (0.60) | HSD11B1POLBTDP1CNR2PDE4B | |
| SCHEMBL3802528 | 0.80 | HSD11B1 (0.64) | HSD11B1POLBTDP1HSD17B1CNR2 | |
| SCHEMBL3802530 | 0.80 | HSD11B1 (0.64) | HSD11B1POLBTDP1HSD17B1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229374-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009074789-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-18 | — | — | WO | disclosed |