Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659658 | 0.89 | HSD11B1 (0.36) | ALDH1A1TSHRGAABRD4NPSR1 | |
| SCHEMBL3720941 | 0.80 | HSD11B1 (0.59) | ALDH1A1POLBPDE4BTDP1HSD11B1 | |
| SCHEMBL3718093 | 0.80 | TP53 (0.51) | ALDH1A1TSHRHTTGAAHSD17B10 | |
| SCHEMBL3656140 | 0.76 | SMN1; SMN2 (0.53) | ALDH1A1TSHRHTTGAABRD4 | |
| SCHEMBL3719882 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HTTLMNAPOLBTDP1 | |
| SCHEMBL3661895 | 0.73 | ALDH1A1 (0.45) | ALDH1A1HTTFDFT1POLBMAPT | |
| SCHEMBL13125193 | 0.72 | ALDH1A1 (0.45) | ALDH1A1GAAHSD17B10NPSR1KDM4E | |
| SCHEMBL3662438 | 0.71 | PIK3CA (0.41) | ALDH1A1HTTBRD4FDFT1KDM4E | |
| SCHEMBL4440022 | 0.71 | DPP4 (0.39) | ALDH1A1HTTGAAPOLBSMN1; SMN2 | |
| SCHEMBL4767291 | 0.68 | CTSK (0.38) | ALDH1A1HTTGAAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229374-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009074789-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-18 | — | — | WO | disclosed |