Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661604 | 0.89 | ALDH1A1 (0.40) | HSD11B1L3MBTL1TSHRBRD4PDE4B | |
| SCHEMBL3720941 | 0.83 | HSD11B1 (0.59) | HSD11B1PDE4BALDH1A1 | |
| SCHEMBL3719882 | 0.79 | ALDH1A1 (0.42) | HSD11B1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3662946 | 0.76 | KDM4E (0.52) | MEN1MAPTKMT2ANPSR1KDM4E | |
| SCHEMBL13160414 | 0.75 | GPR119 (0.37) | HSD11B1L3MBTL1TSHRDAOBRD4 | |
| SCHEMBL4440022 | 0.73 | DPP4 (0.39) | L3MBTL1ALDH1A1GAAMGLL | |
| SCHEMBL3657468 | 0.72 | SMN1; SMN2 (0.58) | PDE4BMEN1KMT2ANPSR1 | |
| SCHEMBL4440020 | 0.72 | SRD5A1 (0.49) | ALDH1A1KMT2ALMNA | |
| SCHEMBL4767291 | 0.70 | CTSK (0.38) | L3MBTL1ALDH1A1GAA | |
| SCHEMBL3664088 | 0.70 | GAA (0.35) | L3MBTL1ALDH1A1GAAKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229374-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009074789-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-18 | — | — | WO | disclosed |