SCHEMBL3721020

SCHEMBL3721020

NCc1cc(-c2cccc(C(F)(F)F)c2)nc(N2CCN(c3ccccc3F)CC2)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.43
CYP2C19 P33261 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 2/20 0.43
CYP2C9 P11712 2/20 0.43
ALDH1A1 P00352 2/20 0.43
NPC1 O15118 1/20 0.43
CYP2D6 P10635 1/20 0.41
TSHR P16473 2/20 0.40
CTSK P43235 6/20 0.40
KCNH2 Q12809 5/20 0.40
MAPK1 P28482 2/20 0.40
CTSS P25774 2/20 0.40
HSD17B10 Q99714 1/20 0.40
CTSB P07858 1/20 0.40
ATM Q13315 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
AR P10275 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3721032 0.90 CYP1A2 (0.44) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3721778 0.87 SMN1; SMN2 (0.46) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3718590 0.87 ALDH1A1 (0.52) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3726353 0.85 ALDH1A1 (0.44) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3717857 0.85 CYP1A2 (0.44) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3720821 0.83 SMN1; SMN2 (0.45) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3720242 0.83 HRH4 (0.46) SMN1; SMN2LMNAALDH1A1NPC1CTSK
SCHEMBL3727042 0.83 DRD2 (0.47) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3721047 0.83 SMN1; SMN2 (0.45) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9
SCHEMBL3721015 0.82 KDM4E (0.55) CYP1A2CYP2C19SMN1; SMN2LMNACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed