SCHEMBL3721778

SCHEMBL3721778

NCc1cc(-c2cccc(F)c2)nc(N2CCN(c3ccccc3F)CC2)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 7/20 0.46
ALDH1A1 P00352 5/20 0.46
LMNA P02545 3/20 0.46
NPC1 O15118 1/20 0.46
KDM4E B2RXH2 2/20 0.40
POLB P06746 1/20 0.40
TSHR P16473 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
MAPT P10636 2/20 0.39
HPGD P15428 1/20 0.39
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP2C9 P11712 1/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
DHFR P00374 1/20 0.39
MAPK1 P28482 2/20 0.39
USP2 O75604 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3721047 0.91 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3718590 0.91 ALDH1A1 (0.52) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3726353 0.89 ALDH1A1 (0.44) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3727042 0.89 DRD2 (0.47) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3721020 0.87 CYP1A2 (0.43) SMN1; SMN2ALDH1A1LMNANPC1TSHR
SCHEMBL3720821 0.86 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3720242 0.86 HRH4 (0.46) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3724712 0.85 LMNA (0.42) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3717916 0.85 LMNA (0.42) SMN1; SMN2ALDH1A1LMNANPC1KDM4E
SCHEMBL3717857 0.85 CYP1A2 (0.44) SMN1; SMN2ALDH1A1LMNANPC1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed