SCHEMBL3721047

SCHEMBL3721047

NCc1cc(-c2cc(F)cc(F)c2)nc(N2CCN(c3ccccc3F)CC2)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.45
ALDH1A1 P00352 3/20 0.45
LMNA P02545 3/20 0.45
NPC1 O15118 1/20 0.45
DRD4 P21917 3/20 0.39
DRD3 P35462 2/20 0.39
DRD2 P14416 1/20 0.39
HRH4 Q9H3N8 1/20 0.39
POLB P06746 2/20 0.39
TSHR P16473 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 3/20 0.38
NFKB1 P19838 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HSD17B10 Q99714 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3721778 0.91 SMN1; SMN2 (0.46) SMN1; SMN2ALDH1A1LMNANPC1DRD4
SCHEMBL3727042 0.91 DRD2 (0.47) SMN1; SMN2ALDH1A1LMNANPC1DRD4
SCHEMBL3718590 0.91 ALDH1A1 (0.52) SMN1; SMN2ALDH1A1LMNANPC1HRH4
SCHEMBL3722201 0.89 ALDH1A1 (0.46) SMN1; SMN2ALDH1A1LMNANPC1HRH4
SCHEMBL3721161 0.86 MAPT (0.44) SMN1; SMN2ALDH1A1LMNANPC1DRD4
SCHEMBL3721099 0.86 SMN1; SMN2 (0.44) SMN1; SMN2ALDH1A1LMNANPC1DRD4
SCHEMBL3717916 0.84 LMNA (0.42) SMN1; SMN2ALDH1A1LMNANPC1DRD4
SCHEMBL3724712 0.84 LMNA (0.42) SMN1; SMN2ALDH1A1LMNANPC1DRD4
SCHEMBL3726353 0.84 ALDH1A1 (0.44) SMN1; SMN2ALDH1A1LMNANPC1DRD4
SCHEMBL3721032 0.84 CYP1A2 (0.44) SMN1; SMN2ALDH1A1LMNANPC1DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed