Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 2/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802196 | 0.88 | HSD11B1 (0.39) | HSD11B1MCHR1LMNAROCK2TNKS2 | |
| SCHEMBL3665796 | 0.85 | HSD11B1 (0.37) | HSD11B1MCHR1NPC1RAB9A | |
| SCHEMBL3792452 | 0.82 | MDM2 (0.40) | HSD11B1MCHR1NPC1LMNAHTT | |
| SCHEMBL9982786 | 0.82 | LIPE (0.39) | HSD11B1MCHR1 | |
| SCHEMBL3667493 | 0.81 | HSD11B1 (0.38) | HSD11B1MCHR1ROCK2 | |
| SCHEMBL3662832 | 0.78 | HRH3 (0.43) | HSD11B1MCHR1ROCK2TNKS2 | |
| SCHEMBL3664852 | 0.77 | HSD11B1 (0.41) | HSD11B1NPC1RAB9ALDHA | |
| SCHEMBL27809384 | 0.76 | SLC6A7 (0.43) | HSD11B1KDM4E | |
| SCHEMBL3792118 | 0.76 | HSD11B1 (0.41) | HSD11B1LMNAHTTTNKS2KDM4E | |
| SCHEMBL3666304 | 0.74 | HSD11B1 (0.42) | HSD11B1NPC1LMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238126-A2 | DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | claimed |
| WO-2009112691-A2 | DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2009-09-17 | — | — | WO | claimed |