SCHEMBL3721798

SCHEMBL3721798

NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCN(Cc3ccccc3Cl)CC2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.45
SMN1; SMN2 Q16637 4/20 0.45
MAPT P10636 3/20 0.45
TDP1 Q9NUW8 1/20 0.45
CASP1 P29466 1/20 0.44
CASP4 P49662 1/20 0.44
CASP5 P51878 1/20 0.44
TSHR P16473 1/20 0.43
KDM4E B2RXH2 3/20 0.43
PLA2G1B P04054 1/20 0.43
RAB9A P51151 1/20 0.43
ATG4B Q9Y4P1 1/20 0.43
HTT P42858 1/20 0.42
PARP1 P09874 1/20 0.41
PARP2 Q9UGN5 1/20 0.41
GAA P10253 1/20 0.41
DRD2 P14416 1/20 0.41
DRD4 P21917 1/20 0.41
DRD3 P35462 1/20 0.41
SIGMAR1 Q99720 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3717694 0.89 TSHR (0.43) ALDH1A1SMN1; SMN2MAPTCASP1CASP4
SCHEMBL3717911 0.86 TSHR (0.43) SMN1; SMN2TDP1CASP1CASP4CASP5
SCHEMBL3721797 0.84 KDM4E (0.52) ALDH1A1SMN1; SMN2MAPTTDP1CASP1
SCHEMBL3727016 0.84 CASP1 (0.53) ALDH1A1MAPTCASP1CASP4CASP5
SCHEMBL3717029 0.83 SRPK1 (0.46) ALDH1A1CASP1CASP4CASP5KDM4E
SCHEMBL3797918 0.81 HRH4 (0.44) ALDH1A1SMN1; SMN2TDP1CASP1CASP4
SCHEMBL3717051 0.80 KDM4E (0.54) ALDH1A1MAPTTDP1CASP1CASP4
SCHEMBL3724664 0.79 HRH4 (0.57) ALDH1A1SMN1; SMN2MAPTKDM4EHTT
SCHEMBL3721072 0.79 CYP11B2 (0.46) ALDH1A1SMN1; SMN2MAPTTDP1CASP1
SCHEMBL3721032 0.79 CYP1A2 (0.44) ALDH1A1SMN1; SMN2MAPTTDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed