Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRPK1 | Q96SB4 | 17/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP4 | P49662 | 1/20 | 0.43 |
| ▸ | CASP5 | P51878 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717027 | 0.85 | KDM4E (0.52) | SRPK1KDM4EALDH1A1NPSR1CLK1 | |
| SCHEMBL3727016 | 0.85 | CASP1 (0.53) | SRPK1KDM4EALDH1A1CASP1CASP4 | |
| SCHEMBL3721798 | 0.83 | ALDH1A1 (0.45) | KDM4EALDH1A1CASP1CASP4CASP5 | |
| SCHEMBL3717694 | 0.83 | TSHR (0.43) | ALDH1A1CASP1CASP4CASP5 | |
| SCHEMBL3717051 | 0.83 | KDM4E (0.54) | SRPK1KDM4EALDH1A1CASP1CASP4 | |
| SCHEMBL3797918 | 0.82 | HRH4 (0.44) | KDM4EALDH1A1CASP1CASP4CASP5 | |
| SCHEMBL3721072 | 0.82 | CYP11B2 (0.46) | KDM4EALDH1A1CASP1CASP4CASP5 | |
| SCHEMBL3717911 | 0.81 | TSHR (0.43) | KDM4ECASP1CASP4CASP5 | |
| SCHEMBL3724664 | 0.80 | HRH4 (0.57) | KDM4EALDH1A1 | |
| SCHEMBL3721032 | 0.80 | CYP1A2 (0.44) | KDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |