Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722862 | 0.91 | P2RX7 (0.43) | P2RX7EPHX2MAPK10MAPK8 | |
| SCHEMBL2787523 | 0.88 | L3MBTL1 (0.43) | P2RX7EPHX2L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL2788143 | 0.88 | L3MBTL1 (0.42) | P2RX7EPHX2L3MBTL1KMT2A | |
| SCHEMBL13191711 | 0.86 | P2RX7 (0.37) | P2RX7EPHX2MAPK10MAPK8PDE4B | |
| SCHEMBL3728281 | 0.86 | P2RX7 (0.38) | P2RX7EPHX2MAPK10MAPK8PDE4B | |
| SCHEMBL3722075 | 0.85 | P2RX7 (0.37) | P2RX7EPHX2MAPK10MAPK8PDE4B | |
| SCHEMBL13165651 | 0.84 | MAPT (0.45) | P2RX7EPHX2L3MBTL1KMT2A | |
| SCHEMBL13191712 | 0.83 | BDKRB1 (0.38) | P2RX7EPHX2PDE4BCNR2 | |
| SCHEMBL3722055 | 0.83 | P2RX7 (0.35) | P2RX7EPHX2MAPK8PDE4BCNR2 | |
| SCHEMBL3725868 | 0.82 | MEN1 (0.41) | P2RX7EPHX2PDE4BCNR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |