Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723967 | 0.82 | MMP9 (0.55) | GAACKS1BSKP1SKP2MEN1 | |
| SCHEMBL3724621 | 0.79 | CKS1B (0.44) | GAACKS1BSKP1SKP2MEN1 | |
| SCHEMBL31393816 | 0.74 | TDP1 (0.45) | DRD2LMNAGAAHPGDCKS1B | |
| SCHEMBL5769720 | 0.74 | CKS1B (0.43) | DRD2LMNAGAAHPGDCKS1B | |
| SCHEMBL29168148 | 0.73 | NQO2 (0.57) | DRD2LMNAGAAHPGDMEN1 | |
| SCHEMBL31117833 | 0.73 | CKS1B (0.45) | DRD2LMNAGAAHPGDCKS1B | |
| SCHEMBL15283620 | 0.71 | CKS1B (0.50) | DRD2GAACKS1BSKP1SKP2 | |
| SCHEMBL1683198 | 0.71 | KMT2A (0.52) | DRD2LMNAGAAHPGDMEN1 | |
| SCHEMBL15189256 | 0.71 | NPC1 (0.52) | LMNAGAACKS1BSKP1SKP2 | |
| SCHEMBL4706536 | 0.70 | GAA (0.51) | DRD2LMNAGAAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125103-A1 | DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |