Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 6/20 | 0.61 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.53 |
| ▸ | F11 | P03951 | 1/20 | 0.52 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.52 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27352380 | 0.89 | ERN1 (0.54) | CFDAOC3ERN1PARP1DHODH | |
| SCHEMBL509423 | 0.89 | LOXL2 (0.66) | CFDLOXL2PARP1 | |
| SCHEMBL29364575 | 0.89 | LOXL2 (0.66) | CFDLOXL2PARP1 | |
| SCHEMBL3722171 | 0.88 | AOC3 (0.63) | CFDLOXL2AOC3 | |
| SCHEMBL9842445 | 0.87 | LOXL2 (0.58) | CFDLOXL2PARP1 | |
| SCHEMBL1788673 | 0.86 | TAAR1 (0.49) | CFDAOC3ERN1PARP1DHODH | |
| SCHEMBL1252499 | 0.86 | CFD (0.66) | CFDLOXL2F11TPSB2SUCNR1 | |
| SCHEMBL4940681 | 0.86 | IKBKB (0.56) | CFDAOC3ERN1PARP1DHODH | |
| SCHEMBL2431097 | 0.84 | PARP1 (0.64) | ERN1PARP1DHODH | |
| SCHEMBL31422694 | 0.84 | PARP1 (0.64) | ERN1PARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | claimed |
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |
| CN-100345847-C | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | disclosed |