Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | C1R | P00736 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674037 | 0.89 | FGFR1 (0.52) | PDE5AAURKAPARP1AMY1AFGFR1 | |
| SCHEMBL7669897 | 0.85 | PDE2A (0.60) | PARP1GUSBABCG2RAB9ANPC1 | |
| SCHEMBL7672854 | 0.85 | KDM4E (0.50) | GUSBABCG2RAB9ANPC1KDM4E | |
| SCHEMBL10628266 | 0.84 | PDE5A (0.42) | PDE5AAURKAPARP1AMY1AFGFR1 | |
| SCHEMBL7674286 | 0.79 | GUSB (0.64) | PARP1GUSBNPC1KDM4EMEN1 | |
| SCHEMBL6887071 | 0.79 | ALDH1A1 (0.52) | PARP1FGFR1RAB9ANPC1KDM4E | |
| SCHEMBL11245650 | 0.79 | PDE5A (0.46) | PDE5APARP1GUSBRAB9ANPC1 | |
| SCHEMBL31027930 | 0.78 | AMY1A (0.76) | PDE5AAURKAPARP1AMY1ARAB9A | |
| SCHEMBL2096956 | 0.78 | AMY1A (0.76) | PDE5AAURKAPARP1AMY1ARAB9A | |
| SCHEMBL11332812 | 0.77 | NPC1 (0.61) | FGFR1FGFR2RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227460-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009053694-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
| US-6479499-B1 | INHIBITORS OF TUBULIN POLYMERIZATION | NATIONAL SCIENCE COUNCIL (TW) | 2002-11-12 | — | — | US | disclosed |