Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 4/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.39 |
| ▸ | ATP4A | P20648 | 3/20 | 0.39 |
| ▸ | ATP4B | P51164 | 3/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433146 | 0.86 | ATP4A (0.41) | AGERHRH3ATP4AATP4BACHE | |
| SCHEMBL676481 | 0.85 | HRH2 (0.49) | HRH3ACHE | |
| SCHEMBL3423187 | 0.84 | AGER (0.41) | AGERPIM1HRH3ATP4AATP4B | |
| SCHEMBL674976 | 0.82 | DRD3 (0.43) | AGER | |
| SCHEMBL3725266 | 0.82 | ALK (0.40) | AGERPIM1HRH3ATP4AATP4B | |
| SCHEMBL3426131 | 0.82 | ATP4A (0.39) | AGERPIM1HRH3ATP4AATP4B | |
| SCHEMBL675732 | 0.81 | KDM4E (0.43) | — | |
| SCHEMBL3426129 | 0.80 | DRD2 (0.39) | PIM1HRH3ATP4AATP4BPIM2 | |
| SCHEMBL3433144 | 0.79 | HRH3 (0.40) | AGERHRH3ATP4AATP4BACHE | |
| SCHEMBL3432969 | 0.77 | LSS (0.42) | HRH3ATP4AATP4BACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |