Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 1/20 | 0.41 |
| ▸ | ATP4B | P51164 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 6/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426129 | 0.92 | DRD2 (0.39) | ATP4AATP4BHRH3ACHEDRD2 | |
| SCHEMBL3432969 | 0.91 | LSS (0.42) | ATP4AATP4BHRH3ACHE | |
| SCHEMBL3722601 | 0.88 | HRH3 (0.41) | ATP4AATP4BHRH3ACHEDRD2 | |
| SCHEMBL3423190 | 0.87 | HRH3 (0.40) | ATP4AATP4BHRH3ACHEDRD2 | |
| SCHEMBL3722600 | 0.86 | AGER (0.40) | ATP4AATP4BAGERHRH3ACHE | |
| SCHEMBL3426135 | 0.84 | HRH3 (0.39) | ATP4AATP4BHRH3ACHEDRD2 | |
| SCHEMBL3423187 | 0.84 | AGER (0.41) | ATP4AATP4BAGERHRH3ACHE | |
| SCHEMBL3426131 | 0.84 | ATP4A (0.39) | ATP4AATP4BAGERHRH3ACHE | |
| SCHEMBL674726 | 0.84 | ACHE (0.46) | ATP4AATP4BAGERHRH3ACHE | |
| SCHEMBL3724896 | 0.84 | CCNB2 (0.44) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| WO-2010025872-A2 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2010-03-11 | — | — | WO | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |