Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | LDHB | P07195 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721092 | 0.86 | SCN9A (0.50) | FPR2SCN9ALDHBLDHA | |
| SCHEMBL1733575 | 0.83 | FPR2 (0.55) | FPR2SCN9AALDH1A1AGTR1KDM4E | |
| SCHEMBL3718054 | 0.78 | GRM2 (0.46) | FPR2SCN9AGRM2AGTR1MCL1 | |
| SCHEMBL1735244 | 0.75 | FPR2 (0.50) | FPR2SCN9AALDH1A1AGTR1KDM4E | |
| SCHEMBL1735520 | 0.75 | KDM4E (0.56) | FPR2SCN9AALDH1A1KDM4ELMNA | |
| SCHEMBL1735518 | 0.74 | KDM4E (0.50) | FPR2SCN9AALDH1A1KDM4ELMNA | |
| SCHEMBL1733664 | 0.73 | TDP1 (0.65) | FPR2SCN9AALDH1A1AGTR1KDM4E | |
| SCHEMBL3727320 | 0.73 | SCN9A (0.43) | FPR2SCN9AALDH1A1GRM2AGTR1 | |
| SCHEMBL6082153 | 0.73 | MAPK14 (0.54) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1733671 | 0.73 | KDM4E (0.53) | FPR2SCN9AALDH1A1AGTR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |