Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 6/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913766 | 0.77 | VNN1 (0.43) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL914058 | 0.75 | VNN1 (0.41) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL13734933 | 0.75 | SYK (0.66) | SYKRPS6KB1 | |
| SCHEMBL2696548 | 0.72 | VNN1 (0.45) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3712006 | 0.71 | RPS6KB1 (0.63) | RPS6KB1AKT1 | |
| SCHEMBL913839 | 0.69 | EGFR (0.57) | SYK | |
| SCHEMBL30240978 | 0.68 | SYK (0.57) | SYKRPS6KB1 | |
| SCHEMBL30504149 | 0.68 | RPS6KB1 (0.64) | RPS6KB1 | |
| SCHEMBL30315919 | 0.66 | BCAT2 (0.46) | SYKRPS6KB1AKT1 | |
| SCHEMBL20491534 | 0.66 | VNN1 (0.78) | VNN1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |