Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723065 | 0.86 | MKNK1 (0.49) | ROCK2POLBMELKROCK1 | |
| SCHEMBL3713992 | 0.79 | ROCK2 (1.00) | ROCK2KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL3661420 | 0.77 | CDK2 (0.44) | ROCK2KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL3717171 | 0.76 | ROCK2 (0.41) | ROCK2GSK3BDYRK1AROCK1 | |
| SCHEMBL3723999 | 0.76 | MAP4K1 (0.56) | ROCK2KDM4EKMT2AROCK1 | |
| SCHEMBL2368605 | 0.74 | ALDH1A1 (0.47) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL3656438 | 0.74 | ALDH1A1 (0.67) | ROCK2KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL3801726 | 0.73 | ROCK2 (0.69) | ROCK2KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL1987965 | 0.73 | MEN1 (0.48) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL3252024 | 0.72 | ROCK2 (0.50) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |