Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716217 | 0.86 | SMN1; SMN2 (0.44) | ALDH1A1TDP1POLBMAPTMEN1 | |
| SCHEMBL3722179 | 0.84 | SMN1; SMN2 (0.42) | ALDH1A1TDP1POLBMAPTMEN1 | |
| SCHEMBL11020554 | 0.79 | ALDH1A1 (0.56) | ALDH1A1TDP1POLBMAPTHPGD | |
| SCHEMBL11020556 | 0.78 | ALDH1A1 (0.55) | ALDH1A1TDP1POLBMAPTHPGD | |
| SCHEMBL3528024 | 0.77 | ALDH1A1 (0.53) | ALDH1A1TDP1POLBMAPTHPGD | |
| SCHEMBL4260559 | 0.75 | MEN1 (0.56) | ALDH1A1TDP1POLBMAPTHPGD | |
| SCHEMBL12556585 | 0.74 | MEN1 (0.51) | ALDH1A1TDP1POLBMAPTHPGD | |
| SCHEMBL20891948 | 0.74 | ALDH1A1 (0.59) | ALDH1A1TDP1POLBMAPTHPGD | |
| SCHEMBL3442518 | 0.74 | ALDH1A1 (0.70) | ALDH1A1TDP1POLBMAPTHPGD | |
| SCHEMBL4494985 | 0.74 | MEN1 (0.50) | ALDH1A1TDP1POLBMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |