Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722179 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1POLBTDP1THRB | |
| SCHEMBL3723384 | 0.86 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1POLBTDP1MEN1 | |
| SCHEMBL3713598 | 0.70 | MEN1 (0.36) | MEN1KMT2A | |
| SCHEMBL6016541 | 0.69 | THRB (0.66) | POLBTHRBRXFP1NTRK1MEN1 | |
| SCHEMBL1014948 | 0.69 | MEN1 (0.46) | ALDH1A1POLBTDP1THRBRXFP1 | |
| SCHEMBL16415196 | 0.68 | PDE4B (0.39) | MEN1KMT2A | |
| SCHEMBL6872458 | 0.67 | KMT2A (0.63) | SMN1; SMN2ALDH1A1POLBTDP1THRB | |
| SCHEMBL1587409 | 0.67 | KMT2A (0.44) | SMN1; SMN2ALDH1A1POLBTDP1THRB | |
| SCHEMBL1014147 | 0.67 | KMT2A (0.44) | SMN1; SMN2ALDH1A1POLBTDP1THRB | |
| SCHEMBL46639 | 0.66 | MEN1 (0.53) | ALDH1A1POLBTDP1THRBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |