Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.39 |
| ▸ | TTK | P33981 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716217 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1POLBTDP1THRB | |
| SCHEMBL3723384 | 0.84 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1POLBTDP1KDM4E | |
| SCHEMBL3713598 | 0.80 | MEN1 (0.36) | MEN1KMT2ASYK | |
| SCHEMBL3718972 | 0.77 | CYP3A4 (0.43) | MEN1KMT2ASYK | |
| SCHEMBL13733958 | 0.73 | JAK2 (0.47) | PIM1PIM2TTKMEN1KMT2A | |
| SCHEMBL3715143 | 0.73 | MAP3K5 (0.51) | SYK | |
| SCHEMBL2713930 | 0.71 | OPRM1 (0.39) | ALDH1A1SYK | |
| SCHEMBL3718752 | 0.70 | SYK (0.44) | SYK | |
| SCHEMBL1313173 | 0.68 | MAPK8 (0.58) | SMN1; SMN2ALDH1A1PDE4BMAPTSYK | |
| SCHEMBL913766 | 0.67 | VNN1 (0.43) | SMN1; SMN2ALDH1A1POLBTDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |