Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 4/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.31 |
| ▸ | CPB1 | P15086 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31332957 | 0.76 | APOBEC3A (0.39) | APOBEC3AAPOBEC3GKDM2BKDM4CHPGD | |
| SCHEMBL3054669 | 0.66 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GKDM2BKDM4CHPGD | |
| SCHEMBL21879818 | 0.66 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GKDM2BKDM4CKDM5A | |
| SCHEMBL67836 | 0.66 | APOBEC3A (0.50) | APOBEC3AAPOBEC3GKDM2BKDM4CMAPT | |
| SCHEMBL23716719 | 0.65 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GKDM2BKDM4CHPGD | |
| SCHEMBL14710278 | 0.65 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GKDM2BKDM4CMAPT | |
| SCHEMBL21880074 | 0.65 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GKDM2BKDM4CKDM5A | |
| Methylamine SCHEMBL5149607 | 0.64 | APOBEC3A (0.47) | APOBEC3AAPOBEC3GKDM2BKDM4CHPGD | |
| SCHEMBL5937208 | 0.64 | ALDH1A1 (0.47) | APOBEC3AAPOBEC3GMAPTHPGDALDH1A1 | |
| SCHEMBL14736244 | 0.64 | APOBEC3A (0.44) | APOBEC3AAPOBEC3GKDM4CMAPTCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393812-B1 | SUBSTITUTED SPIROAMIDES AS B1R-MODULATORS | GRUENENTHAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2393812-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089127-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2010-08-12 | — | — | WO | disclosed |