SCHEMBL3723969

SCHEMBL3723969

NC(=O)c1cccc(-c2ccc(Cl)cc2)c1

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.63
NR4A2 P43354 1/20 0.60
MAP4K4 O95819 3/20 0.58
ERN1 O75460 2/20 0.55
DHODH Q02127 3/20 0.53
PLAU P00749 1/20 0.52
RXRA P19793 1/20 0.51
RXRB P28702 1/20 0.51
TDP2 O95551 1/20 0.51
CSF1R P07333 1/20 0.51
FLT1 P17948 1/20 0.51
FLT3 P36888 1/20 0.51
SUCNR1 Q9BXA5 1/20 0.51
CNR1 P21554 1/20 0.50
KAT6A Q92794 1/20 0.50
RORC P51449 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6999225 0.88 DHODH (0.63) PARP1ERN1DHODHTDP2CSF1R
SCHEMBL5479593 0.87 PARP1 (0.78) PARP1NR4A2ERN1DHODHPLAU
SCHEMBL1345869 0.87 ALDH1A1 (0.51) PARP1NR4A2MAP4K4ERN1PLAU
SCHEMBL29941476 0.86 DHODH (0.68) PARP1ERN1DHODHTDP2CSF1R
SCHEMBL2589651 0.86 ERN1 (0.60) PARP1ERN1DHODHTDP2CSF1R
SCHEMBL31422694 0.86 PARP1 (0.64) PARP1ERN1DHODHTDP2
SCHEMBL2431097 0.86 PARP1 (0.64) PARP1ERN1DHODHTDP2
SCHEMBL43553 0.84 DHODH (0.70) PARP1ERN1DHODHCSF1RFLT1
SCHEMBL29788172 0.84 DHODH (0.70) PARP1ERN1DHODHCSF1RFLT1
SCHEMBL307574 0.83 RXRA (0.73) MAP4K4ERN1RXRARXRBSUCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
EP-3303299-A1 IMIDAZOLE DERIVATIVES H. Hoffnabb-La Roche Ag (CH) 2018-04-11 EP disclosed
WO-2016193235-A1 IMIDAZOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2016-12-08 WO disclosed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed