Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 3/20 | 0.57 |
| ▸ | MMP12 | P39900 | 3/20 | 0.57 |
| ▸ | MMP3 | P08254 | 2/20 | 0.57 |
| ▸ | MMP10 | P09238 | 2/20 | 0.57 |
| ▸ | MMP8 | P22894 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PTAFR | P25105 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724633 | 0.88 | MMP7 (0.69) | MMP7MMP12MMP3MMP10MMP8 | |
| SCHEMBL4937089 | 0.84 | MMP7 (0.69) | MMP7MMP12MMP3MMP10MMP8 | |
| SCHEMBL4937077 | 0.84 | MMP7 (0.69) | MMP7MMP12MMP3MMP10MMP8 | |
| SCHEMBL3728686 | 0.84 | ALDH1A1 (0.57) | BRD4ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL3809256 | 0.83 | HRH3 (0.60) | MMP7MMP12MMP3MMP10MMP8 | |
| SCHEMBL3725967 | 0.83 | ALDH1A1 (0.55) | BRD4ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4937732 | 0.81 | PTAFR (0.71) | MMP7MMP12MMP3MMP10MMP8 | |
| SCHEMBL23022544 | 0.80 | BRD4 (0.52) | MMP7MMP12MMP3MMP10MMP8 | |
| SCHEMBL3805262 | 0.79 | HRH3 (0.50) | BRD4ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL3805265 | 0.79 | HRH3 (0.50) | BRD4ALDH1A1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |