Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726793 | 0.95 | ADRB2 (0.40) | MAPTTDP1HRH3TOP2AKDM4E | |
| SCHEMBL3720757 | 0.89 | PPARG (0.38) | MAPTTDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3718613 | 0.86 | HRH3 (0.41) | HRH3TLR7CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3719670 | 0.84 | MCHR1 (0.37) | MAPTTDP1 | |
| SCHEMBL3724297 | 0.84 | ACACB (0.38) | MAPTTDP1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3724603 | 0.82 | MTNR1A (0.47) | HRH3 | |
| SCHEMBL3724671 | 0.82 | PDE4B (0.44) | MAPTHRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3724233 | 0.82 | ACACB (0.37) | — | |
| SCHEMBL3724495 | 0.81 | PDE3B (0.34) | — | |
| SCHEMBL3724196 | 0.81 | KEAP1 (0.41) | HRH3KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |