Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALAD | P13716 | 2/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 3/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721441 | 0.86 | DYRK1A (0.44) | ALADGPR35DYRK1ADYRK1BAKT1 | |
| SCHEMBL939164 | 0.72 | GPR35 (0.45) | GPR35DYRK1ADYRK1BAKT1AKT2 | |
| SCHEMBL4381926 | 0.72 | ALAD (0.66) | ALADIKBKETBK1DAOHDAC6 | |
| SCHEMBL3506781 | 0.72 | AKT1 (0.48) | GPR35AKT1AKT2ROCK2ERN1 | |
| SCHEMBL505511 | 0.71 | ALAD (0.70) | ALADDAOHDAC6 | |
| SCHEMBL6143622 | 0.70 | ALAD (0.69) | ALADIKBKETBK1DAOHDAC6 | |
| SCHEMBL3725272 | 0.70 | ALDH1A1 (0.57) | GPR35AKT1AKT2IKBKETBK1 | |
| SCHEMBL26682346 | 0.70 | ALAD (0.50) | ALADDYRK1AIKBKETBK1DAO | |
| SCHEMBL3725804 | 0.70 | DAO (0.46) | GPR35AKT1AKT2DAOROCK2 | |
| SCHEMBL3724691 | 0.70 | GPR35 (0.52) | GPR35AKT1AKT2DAOROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |