Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.37 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724785 | 0.87 | ROCK2 (0.42) | GPR35ROCK2ROCK1 | |
| SCHEMBL3724691 | 0.82 | GPR35 (0.52) | DAOGPR35ROCK2ROCK1AKT1 | |
| SCHEMBL3728328 | 0.78 | GPR35 (0.46) | GPR35ROCK2ROCK1AKT1 | |
| SCHEMBL6267316 | 0.74 | DAO (0.55) | DAO | |
| SCHEMBL6256292 | 0.71 | DAO (0.52) | DAO | |
| SCHEMBL5924808 | 0.70 | DAO (0.50) | DAOGPR35 | |
| SCHEMBL3724784 | 0.70 | ALAD (0.50) | DAOGPR35ROCK2AKT1AKT2 | |
| SCHEMBL3725272 | 0.70 | ALDH1A1 (0.57) | GPR35ROCK2AKT1AKT2 | |
| SCHEMBL20168369 | 0.69 | ROCK2 (0.56) | GPR35ROCK2ROCK1AKT1AKT2 | |
| SCHEMBL3725063 | 0.68 | ROCK2 (0.41) | GPR35ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |