Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | POLQ | O75417 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 2/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722206 | 0.80 | POLQ (0.52) | L3MBTL1CREBBPPOLQ | |
| SCHEMBL13260970 | 0.80 | POLQ (0.48) | L3MBTL1CREBBPNAMPTPOLQSCD | |
| SCHEMBL3724299 | 0.80 | POLQ (0.50) | L3MBTL1CREBBPPOLQ | |
| SCHEMBL13555495 | 0.77 | L3MBTL1 (0.58) | L3MBTL1CREBBPNAMPTFFAR4 | |
| SCHEMBL2326735 | 0.76 | HDAC6 (0.57) | — | |
| SCHEMBL3765456 | 0.75 | KLKB1 (0.53) | L3MBTL1CREBBPSCD5 | |
| SCHEMBL5406806 | 0.73 | KDR (0.56) | IKBKEPIK3CD | |
| SCHEMBL14340939 | 0.72 | L3MBTL1 (0.58) | L3MBTL1CREBBPNAMPTFFAR4DHODH | |
| SCHEMBL3731459 | 0.72 | L3MBTL1 (0.51) | L3MBTL1CREBBPNAMPTPOLQSCD | |
| SCHEMBL27826834 | 0.71 | ABL1 (0.51) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |