Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 11/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722206 | 0.89 | POLQ (0.52) | POLQCREBBPL3MBTL1KDM4EKMT2A | |
| SCHEMBL13260970 | 0.83 | POLQ (0.48) | POLQCREBBPL3MBTL1KDM4EKMT2A | |
| SCHEMBL3725838 | 0.81 | KDM4E (0.45) | CREBBPKDM4EKMT2ASMN1; SMN2POLB | |
| SCHEMBL3724788 | 0.80 | L3MBTL1 (0.52) | POLQCREBBPL3MBTL1 | |
| SCHEMBL3724975 | 0.75 | KDM4E (0.45) | KDM4EKMT2ASMN1; SMN2POLBTDP1 | |
| SCHEMBL3724448 | 0.74 | POLQ (0.41) | POLQCREBBPKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL3765456 | 0.73 | KLKB1 (0.53) | CREBBPL3MBTL1KDM4EPOLBTDP1 | |
| SCHEMBL13260110 | 0.73 | KDM4E (0.43) | POLQCREBBPKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL3731459 | 0.73 | L3MBTL1 (0.51) | POLQCREBBPL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL13555495 | 0.73 | L3MBTL1 (0.58) | CREBBPL3MBTL1KDM4EPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |