Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.59 |
| ▸ | ACLY | P53396 | 5/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076401 | 0.89 | THRB (0.55) | FABP4ACLYPTK2BSMN1; SMN2KDM4E | |
| SCHEMBL24102246 | 0.87 | KMT2A (0.61) | FABP4ACLYKDM4ETSHRKMT2A | |
| SCHEMBL29534969 | 0.87 | KMT2A (0.61) | FABP4ACLYKDM4ETSHRKMT2A | |
| SCHEMBL3727556 | 0.87 | ACLY (0.57) | FABP4ACLYPTK2BSMN1; SMN2KDM4E | |
| SCHEMBL3717038 | 0.84 | CYP2C9 (0.60) | FABP4ACLYKDM4ETSHRKMT2A | |
| SCHEMBL398719 | 0.82 | KDM4E (0.71) | ACLYPTK2BKDM4ETSHRKMT2A | |
| SCHEMBL3718315 | 0.82 | KDM4E (0.70) | FABP4PTK2BSMN1; SMN2KDM4ETSHR | |
| SCHEMBL17331322 | 0.82 | CYP2C9 (0.60) | FABP4PTK2BKDM4ETSHRKMT2A | |
| SCHEMBL6394653 | 0.81 | GRM4 (0.57) | ACLYTSHRKMT2A | |
| SCHEMBL3726033 | 0.80 | SLC22A12 (0.65) | FABP4ACLYPTK2BSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |