Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 2/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14838616 | 0.89 | KMT2A (0.59) | GRM4KEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL7594380 | 0.88 | KEAP1 (0.62) | KEAP1NFE2L2SLC40A1KMT2AMEN1 | |
| SCHEMBL5801171 | 0.86 | LMNA (0.61) | KEAP1NFE2L2KMT2AMEN1TSHR | |
| SCHEMBL4007436 | 0.85 | ACLY (0.57) | GRM4KMT2AMEN1TSHRACLY | |
| SCHEMBL8695450 | 0.83 | KMT2A (0.61) | GRM4KEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL2568299 | 0.82 | RECQL (0.58) | GRM4KEAP1KMT2AMEN1TSHR | |
| SCHEMBL3724899 | 0.81 | FABP4 (0.59) | KMT2ATSHRACLY | |
| SCHEMBL6824081 | 0.81 | CYP2D6 (0.60) | GRM4SLC40A1KMT2AMEN1ACLY | |
| SCHEMBL3806499 | 0.81 | ACLY (0.69) | KMT2AMEN1ACLYCCR2 | |
| SCHEMBL22315132 | 0.80 | MEN1 (0.67) | KEAP1NFE2L2KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967196-B1 | Sulfonamide compounds and uses thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1159263-A1 | NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF | Merck & Co., Inc. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000050391-A1 | NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF | MERCK & CO., INC. (US) | 2000-08-31 | — | — | WO | disclosed |
| US-4725283-A | NITROBENZENE DIRECT DYES FOR HUMAN HAIR | L'OREAL (FR) | 1988-02-16 | — | — | US | disclosed |