Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 3/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 7/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893266 | 0.86 | TRPV3 (0.47) | SCN9ATRPV3MAP4K4 | |
| SCHEMBL13728192 | 0.83 | KMO (0.52) | SCN9APARP1 | |
| SCHEMBL13726855 | 0.82 | L3MBTL1 (0.51) | SCN9AMAP4K4 | |
| SCHEMBL29520004 | 0.81 | SCN9A (0.53) | SCN9AFPR2 | |
| SCHEMBL13729587 | 0.80 | KMT2A (0.53) | SCN9AKMT2APARP1IKBKBMAP4K4 | |
| SCHEMBL29594739 | 0.79 | SCN9A (0.44) | SCN9AFPR2MAP4K4 | |
| SCHEMBL2543831 | 0.79 | HDAC6 (0.50) | SCN9AKMT2APARP1MAP4K4 | |
| SCHEMBL29383595 | 0.79 | HDAC6 (0.50) | SCN9AKMT2APARP1MAP4K4 | |
| SCHEMBL3725418 | 0.79 | SCN9A (0.57) | SCN9AKMT2AFPR2PARP1 | |
| SCHEMBL3719609 | 0.78 | KMT2A (0.54) | SCN9AKMT2AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2012151567-A1 | PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |