Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 9/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636154 | 0.80 | GRAMD1A (0.50) | GRAMD1AGCKMKNK1MAPT | |
| SCHEMBL25045930 | 0.68 | P2RX3 (0.53) | GRAMD1AGCKP2RX3MKNK1MAPT | |
| SCHEMBL23778548 | 0.67 | GRAMD1A (0.44) | GRAMD1AGCKP2RX3GRM5 | |
| SCHEMBL31214297 | 0.66 | POLQ (0.54) | GRAMD1AGCK | |
| SCHEMBL3636389 | 0.66 | GRM5 (0.39) | GRAMD1AGCKROCK2GRM5 | |
| SCHEMBL16624055 | 0.65 | ADORA1 (0.52) | GRAMD1AGCKP2RX3MKNK1MAPT | |
| SCHEMBL30458021 | 0.65 | NPC1 (0.46) | GRAMD1AGCKP2RX3MKNK1MAPT | |
| SCHEMBL25281477 | 0.65 | NPC1 (0.46) | GRAMD1AGCKP2RX3MKNK1MAPT | |
| SCHEMBL12761195 | 0.65 | GRAMD1A (0.53) | GRAMD1AGCKMKNK1MAPTKDM4E | |
| SCHEMBL8858676 | 0.65 | GRAMD1A (0.51) | GRAMD1AGCKMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |