Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.50 |
| ▸ | GCK | P35557 | 17/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636389 | 0.85 | GRM5 (0.39) | GRAMD1AGCK | |
| SCHEMBL3638385 | 0.82 | NPC1 (0.40) | — | |
| SCHEMBL1038282 | 0.81 | PSEN1 (0.52) | GRAMD1AGCKMAPTMKNK1 | |
| SCHEMBL3725834 | 0.80 | GRAMD1A (0.39) | GRAMD1AGCKMAPTMKNK1 | |
| SCHEMBL3638175 | 0.80 | PSEN1 (0.36) | GCK | |
| SCHEMBL3639468 | 0.79 | RAB9A (0.51) | MAPT | |
| SCHEMBL3642038 | 0.77 | MKNK1 (0.41) | MAPTMKNK1 | |
| SCHEMBL3636972 | 0.77 | PSEN1 (0.40) | MAPT | |
| SCHEMBL3634100 | 0.77 | KMT2A (0.40) | MAPTMKNK1 | |
| SCHEMBL3633453 | 0.77 | NPC1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |