Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510807 | 0.80 | KEAP1 (0.61) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL5521920 | 0.78 | LMNA (0.68) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL5516887 | 0.75 | HDAC4 (0.64) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL5513620 | 0.75 | CA2 (0.61) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL407414 | 0.74 | KEAP1 (1.00) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL5512931 | 0.74 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL5510248 | 0.74 | CA2 (0.57) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL4662893 | 0.74 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| Hydrochloric Acid SCHEMBL3516799 | 0.73 | KEAP1 (0.96) | LMNASMN1; SMN2KEAP1CA12CA9 | |
| SCHEMBL534569 | 0.72 | LMNA (0.63) | LMNASMN1; SMN2KEAP1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408756-A1 | ALPHA-(N-BENZENESULFONAMIDO)CYCLOALKYL DERIVATIVES | Bristol-Myers Squibb Company (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010108067-A1 | ALPHA-(N-BENZENESULFONAMIDO)CYCLOALKYL DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-09-23 | — | — | WO | disclosed |