Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 3/20 | 0.49 |
| ▸ | FBP1 | P09467 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1277887 | 0.89 | NR1H2 (0.37) | XDHNPC1MAPTRAB9ANR3C2 | |
| SCHEMBL3731361 | 0.86 | XDH (0.49) | XDHFBP1NPC1MAPTRAB9A | |
| SCHEMBL1278010 | 0.82 | XDH (0.65) | XDHFBP1NPC1MAPTRAB9A | |
| SCHEMBL3733383 | 0.81 | MAPT (0.35) | XDHNPC1MAPTRAB9ANR3C2 | |
| SCHEMBL2904421 | 0.79 | GPR35 (0.38) | NPC1MAPTRAB9AKCNH2NR1H2 | |
| SCHEMBL15015037 | 0.77 | XDH (0.35) | XDHNPC1MAPTRAB9ANR3C2 | |
| SCHEMBL1278051 | 0.77 | XDH (0.35) | XDHNPC1MAPTRAB9ANR3C2 | |
| SCHEMBL1278068 | 0.74 | XDH (0.33) | XDHNPC1MAPTRAB9ANR1H2 | |
| SCHEMBL23799465 | 0.72 | XDH (0.42) | XDHMAPTNR1H2L3MBTL1LMNA | |
| SCHEMBL1277966 | 0.72 | XDH (0.74) | XDHFBP1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178869-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025477-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |