Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278051 | 0.96 | XDH (0.35) | MAPTNPC1RAB9AL3MBTL1XDH | |
| SCHEMBL1277887 | 0.91 | NR1H2 (0.37) | MAPTNPC1RAB9AL3MBTL1XDH | |
| SCHEMBL3720400 | 0.89 | ALDH1A1 (0.32) | XDHNR1H2ALDH1A1 | |
| SCHEMBL1277664 | 0.88 | ALDH1A1 (0.35) | MAPTNPC1RAB9AL3MBTL1POLB | |
| SCHEMBL15015037 | 0.86 | XDH (0.35) | MAPTNPC1RAB9AL3MBTL1XDH | |
| SCHEMBL1278068 | 0.83 | XDH (0.33) | MAPTNPC1RAB9AL3MBTL1XDH | |
| SCHEMBL3727035 | 0.81 | XDH (0.49) | MAPTNPC1RAB9AL3MBTL1XDH | |
| SCHEMBL2904421 | 0.80 | GPR35 (0.38) | MAPTNPC1RAB9AL3MBTL1NR1H2 | |
| SCHEMBL3027251 | 0.79 | MEN1 (0.48) | RAB9AL3MBTL1POLBALDH1A1MEN1 | |
| SCHEMBL13769207 | 0.78 | ALDH1A1 (0.35) | MAPTNPC1RAB9AL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178869-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025477-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |