Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | KDM5A | P29375 | 3/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13048257 | 0.83 | BRD4 (0.47) | BRD4KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL3730943 | 0.82 | CYP19A1 (0.45) | KDM5AKDM5BKDM4CKDM4ACYP19A1 | |
| SCHEMBL3726218 | 0.82 | CYP19A1 (0.54) | BRD4KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL24845157 | 0.78 | KDM5B (0.52) | BRD4KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL24844792 | 0.75 | PHF8 (0.51) | BRD4KDM5AKDM5BKDM4CCYP19A1 | |
| SCHEMBL24844768 | 0.75 | CYP11B1 (0.53) | BRD4KDM5AKDM5BKDM4CKDM4A | |
| SCHEMBL19936854 | 0.74 | HPGDS (0.51) | BRD4KDM5AKDM5BKDM4CKDM4A | |
| Iodide SCHEMBL31305035 | 0.73 | AKR1B1 (0.73) | CYP19A1AKR1B1CXCL8KDM4ECYP1A2 | |
| SCHEMBL3737260 | 0.73 | TBXAS1 (0.64) | CYP19A1CYP1A2MAPTTBXAS1PTGDR2 | |
| SCHEMBL9795232 | 0.71 | POLB (0.48) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010142652-A1 | IMIDAZOBENZAZEPINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISEASES | GLAXO GROUP LIMITED (GB) | 2010-12-16 | — | — | WO | disclosed |