Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | NPC1 | O15118 | 9/20 | 0.49 |
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | HPGD | P15428 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731964 | 0.90 | ADORA3 (0.53) | ADORA3CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3738781 | 0.85 | SMN1; SMN2 (0.52) | ADORA3CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3741834 | 0.85 | PTGES (0.55) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL1052507 | 0.81 | HPGD (0.61) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL3728452 | 0.81 | ALDH1A1 (0.53) | ADORA3CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3728503 | 0.80 | FGFR1 (0.56) | ADORA3CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL1054760 | 0.79 | SLC2A1 (0.60) | ADORA3CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3732815 | 0.79 | NPC1 (0.53) | ADORA3CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3738156 | 0.78 | CDK1 (0.46) | ADORA3CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3736757 | 0.78 | ALDH1A1 (0.53) | CDK1CDK2MKNK1MKNK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |