Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300429 | 0.84 | CDK1 (0.41) | FGFR1FLT1CDK1CDK2MKNK1 | |
| SCHEMBL4299851 | 0.83 | JMJD6 (0.42) | FGFR1FLT1CDK1CDK2MKNK1 | |
| SCHEMBL3738781 | 0.80 | SMN1; SMN2 (0.52) | FGFR1CDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3741834 | 0.80 | PTGES (0.55) | CDK1CDK2MKNK1MKNK2ALDH1A1 | |
| SCHEMBL3727870 | 0.80 | ADORA3 (0.50) | CDK1CDK2MKNK1MKNK2ALDH1A1 | |
| SCHEMBL221334 | 0.77 | ALDH1A1 (0.69) | FGFR1FLT1CDK1CDK2MKNK1 | |
| SCHEMBL12676445 | 0.77 | ALDH1A1 (0.69) | FGFR1FLT1CDK1CDK2MKNK1 | |
| SCHEMBL3745904 | 0.77 | PDPK1 (0.52) | CDK1CDK2MKNK1MKNK2ALDH1A1 | |
| SCHEMBL3732791 | 0.77 | CDK1 (0.52) | CDK1CDK2MKNK1MKNK2ALDH1A1 | |
| SCHEMBL3731964 | 0.77 | ADORA3 (0.53) | CDK1CDK2MKNK1MKNK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |