Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadiazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | AURKA | O14965 | 1/20 | 0.96 |
| ▸ | DHFR | P00374 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadiazine SCHEMBL17092959 | 0.98 | LMNA (0.93) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL10422849 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL24176 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL30080807 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL6141086 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870705 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL34517 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL11611850 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870853 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL16860643 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115337447-B | Sulfadiazine silver hydrogel for rapid wound healing and preparation method and application thereof | 苏州弘森药业股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115337447-A | Sulfadiazine silver hydrogel for rapid wound healing and preparation method and application thereof | 苏州弘森药业股份有限公司 | 2022-11-15 | — | — | CN | disclosed |
| EP-2178990-B1 | ANTIMICROBIAL PHOTO-STABLE COATING COMPOSITION | COVALON TECHNOLOGIES LTD (CA) | 2015-07-08 | — | — | EP | disclosed |
| US-8877256-B2 | Antimicrobial photo-stable coating composition | COVALON TECHNOLOGIES LTD. (CA) | 2014-11-04 | — | — | US | disclosed |
| EP-2178990-A1 | ANTIMICROBIAL PHOTO-STABLE COATING COMPOSITION | Covalon Technologies Ltd. (CA) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009015476-A1 | ANTIMICROBIAL PHOTO-STABLE COATING COMPOSITION | COVALON TECHNOLOGIES LTD. (CA) | 2009-02-05 | — | — | WO | disclosed |
| US-20090035388-A1 | ANTIMICROBIAL PHOTO-STABLE COATING COMPOSITION | COVALON TECHNOLOGIES INC. (CA) | 2009-02-05 | — | — | US | disclosed |
| US-6468383-B2 | Hydrogel laminate, bandages and composites and methods for forming the same | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-0610056-B1 | Hydrogel bandages | JOHNSON & JOHNSON CONSUMER (US) | 2002-06-05 | — | — | EP | disclosed |
| US-20010031370-A1 | Hydrogel laminate, bandages and composites and methods for forming the same | KUNDEL NIKHIL K (US) | 2001-10-18 | — | — | US | disclosed |
| US-6228390-B1 | Hydrogel laminate, bandages and composites and methods for forming the same | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | 2001-05-08 | — | — | US | disclosed |
| EP-0604103-B1 | Hydrogel laminate , bandages and composites and methods for forming the same | JOHNSON & JOHNSON CONSUMER (US) | 1999-03-17 | — | — | EP | disclosed |
| US-5674346-A | Hydrogel laminate, bandages and composites and methods for forming the same | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5480717-A | Hydrogel laminate bandages and composites | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. (US) | 1996-01-02 | — | — | US | disclosed |
| EP-0610056-A1 | Hydrogel bandages | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. (US) | 1994-08-10 | — | — | EP | disclosed |
| EP-0604103-A1 | Hydrogel laminate , bandages and composites and methods for forming the same | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. (US) | 1994-06-29 | — | — | EP | disclosed |