Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445492 | 0.84 | DCUN1D1 (0.32) | DCUN1D1ALDH1A1GAA | |
| SCHEMBL3637473 | 0.73 | IMPDH2 (0.43) | ALDH1A1GAA | |
| SCHEMBL6541679 | 0.73 | CA1 (0.38) | ALDH1A1 | |
| SCHEMBL3733422 | 0.69 | PDE5A (0.31) | — | |
| SCHEMBL3722110 | 0.68 | ROCK2 (0.40) | — | |
| SCHEMBL4267696 | 0.68 | — | — | |
| SCHEMBL2039605 | 0.67 | FYN (0.40) | — | |
| SCHEMBL2041601 | 0.67 | CYP2A6 (0.48) | — | |
| SCHEMBL28789059 | 0.67 | ERN1 (0.42) | ALDH1A1 | |
| SCHEMBL230060 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |