Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 8/20 | 0.35 |
| ▸ | DRD2 | P14416 | 7/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724725 | 0.83 | JAK2 (0.39) | JAK2JAK1GRM2CDK4CDK6 | |
| SCHEMBL17554234 | 0.81 | JAK1 (0.39) | JAK2JAK1PIK3CDDRD4DRD2 | |
| SCHEMBL3758694 | 0.76 | JAK1 (0.39) | JAK2JAK1DRD4DRD2DRD3 | |
| SCHEMBL3011705 | 0.70 | VCP (0.41) | JAK2JAK1GRM5PIK3CAPIK3R1 | |
| SCHEMBL27237587 | 0.69 | NR4A2 (0.40) | PIK3CAPIK3CD | |
| SCHEMBL3000153 | 0.69 | CSF1R (0.41) | JAK2JAK1GRM5PIK3CAPIK3R1 | |
| SCHEMBL220097 | 0.67 | SIGMAR1 (0.62) | GRM5SLC2A1 | |
| SCHEMBL13163955 | 0.65 | MCHR1 (0.49) | JAK2JAK1DRD4DRD2DRD3 | |
| SCHEMBL28808590 | 0.63 | VCP (0.43) | JAK2JAK1GRM5SLC2A1DRD4 | |
| SCHEMBL3149433 | 0.62 | ALDH1A1 (0.50) | JAK2JAK1GRM5GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | claimed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | claimed |
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |