Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039954 | 0.72 | EPHX2 (0.32) | — | |
| SCHEMBL3729457 | 0.72 | PLAT (0.34) | GPR119PLAT | |
| SCHEMBL4236595 | 0.70 | GPR119 (0.32) | GPR119PLAT | |
| SCHEMBL1274688 | 0.68 | ALDH1A1 (0.41) | MEN1KMT2A | |
| SCHEMBL6833620 | 0.66 | GPR119 (0.32) | GPR119PLAT | |
| SCHEMBL3073015 | 0.65 | GPR119 (0.33) | GPR119PLATMEN1KMT2A | |
| SCHEMBL4242556 | 0.65 | MEN1 (0.35) | GPR119PLATMEN1KMT2A | |
| SCHEMBL16963472 | 0.63 | NR1H2 (0.59) | GPR119MEN1KMT2A | |
| SCHEMBL16963473 | 0.63 | NR1H2 (0.59) | GPR119MEN1KMT2A | |
| SCHEMBL2811594 | 0.62 | KDM4E (0.34) | GPR119PLATMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825119-B2 | Bone disorders such as osteoporosis, tumors and cardiovascular disorders; 4-(2-carboxy-2-Boc-aminoethylamino)-6-piperidinopyrimidines such as tert-butyl 2-benzyloxycarbonylamino-3-[2,5-dimethoxy-6-(4-[1,8]naphthyridin-2-yl-piperidin-1-yl)pyrimidin-4-ylamino]-propionate | GALAPAGOS SAS (FR) | 2010-11-02 | — | — | US | disclosed |