Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073015 | 0.76 | GPR119 (0.33) | GPR119KDM4EMAPTTHRBNR1H2 | |
| SCHEMBL4242556 | 0.76 | MEN1 (0.35) | GPR119SCN9ASCN3ASCN5AKDM4E | |
| SCHEMBL6833620 | 0.73 | GPR119 (0.32) | GPR119SCN9ASCN3ASCN5AKDM4E | |
| SCHEMBL1420420 | 0.70 | DPP4 (0.32) | GPR119SCN9ASCN3ASCN5AKDM4E | |
| SCHEMBL3729459 | 0.70 | GPR119 (0.36) | GPR119PLAT | |
| SCHEMBL2039954 | 0.68 | EPHX2 (0.32) | — | |
| SCHEMBL1847232 | 0.68 | KDM4E (0.32) | GPR119SCN9ASCN3ASCN5AKDM4E | |
| SCHEMBL1849221 | 0.68 | LIPE (0.32) | GPR119SCN9ASCN3ASCN5APLAT | |
| SCHEMBL1420419 | 0.67 | GPR119 (0.33) | GPR119SCN9ASCN3ASCN5AKDM4E | |
| SCHEMBL1847230 | 0.66 | PLAT (0.33) | GPR119KDM4EMAPTTHRBNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2015748-A2 | METHOD OF INHIBITING C KIT KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-21 | — | — | EP | disclosed |
| EP-1951234-A2 | METHOD OF INHIBITING FLT3 KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007124369-A2 | METHOD OF INHIBITING C KIT KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |
| EP-1807077-A2 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2007048088-A2 | METHOD OF INHIBITING FLT3 KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-26 | — | — | WO | disclosed |
| WO-2006047277-A2 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |