Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.39 |
| ▸ | BRD2 | P25440 | 5/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3729955 | 0.78 | AKT2 (0.38) | BRD4UCHL1HTR1ADRD2 | |
| SCHEMBL841719 | 0.76 | DRD2 (0.42) | BRD4BRD2UCHL1HTR1ADRD2 | |
| SCHEMBL1009909 | 0.75 | DRD2 (0.43) | BRD4BRD2UCHL1HTR1ADRD2 | |
| Ammonia Solution, Strong SCHEMBL3729931 | 0.75 | DRD2 (0.41) | BRD4BRD2UCHL1HTR1ADRD2 | |
| SCHEMBL3725607 | 0.71 | JUN (0.39) | — | |
| SCHEMBL339244 | 0.71 | HTR1A (0.41) | BRD4BRD2UCHL1HTR1ADRD2 | |
| SCHEMBL3737203 | 0.71 | CYP19A1 (0.39) | — | |
| SCHEMBL339245 | 0.69 | DRD2 (0.50) | BRD4BRD2UCHL1HTR1ADRD2 | |
| SCHEMBL3312973 | 0.69 | HTR1A (0.64) | HTR1ADRD2 | |
| SCHEMBL3727066 | 0.69 | ANPEP (0.36) | UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |