Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TERT | O14746 | 7/20 | 0.47 |
| ▸ | PTPRC | P08575 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725859 | 0.83 | RAB9A (0.56) | MEN1NPC1ALDH1A1CYP1A2POLB | |
| SCHEMBL17656935 | 0.79 | MAPT (0.67) | MEN1NPC1ALDH1A1CYP1A2POLB | |
| SCHEMBL11211451 | 0.77 | GAA (0.57) | NPC1ALDH1A1POLBCYP2D6MAPT | |
| SCHEMBL11612210 | 0.71 | MAPT (0.63) | MEN1NPC1ALDH1A1CYP1A2POLB | |
| SCHEMBL397133 | 0.71 | PTPN1 (0.49) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28455725 | 0.70 | RAB9A (0.55) | MEN1NPC1ALDH1A1CYP1A2POLB | |
| SCHEMBL1070746 | 0.70 | GAA (0.46) | ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL22321720 | 0.69 | MAOA (0.83) | MEN1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL4299908 | 0.68 | ALDH1A1 (0.90) | MEN1NPC1ALDH1A1CYP1A2POLB | |
| SCHEMBL11660757 | 0.68 | MAPT (0.69) | MEN1NPC1ALDH1A1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825279-B2 | Fused ring dicationic anti-protozoan agents and their prodrugs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-11-02 | — | — | US | claimed |
| US-20050165044-A1 | Fused ring dicationic anti-protozoan agents and their prodrugs | BOYKIN DAVID W (US) | 2005-07-28 | — | — | US | claimed |
| US-7825279-B2 | Fused ring dicationic anti-protozoan agents and their prodrugs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-11-02 | — | — | US | disclosed |
| US-20050165044-A1 | Fused ring dicationic anti-protozoan agents and their prodrugs | BOYKIN DAVID W (US) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165044-A1 | Fused ring dicationic anti-protozoan agents and their prodrugs | DHODH, DHFR, PAICS | MEN1 1639/4885NPC1 1942/4885ALDH1A1 4131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.